Anti-inflammatory Herb-Boswellia

Boswellia is one of the main ingredients in several FlameEz? remedies. Boswellia is a significant herb in the Ayurvedic system of health and healing and is mainly used for its anti-inflammatory and antiarthritic properties. Historically, it has been recommended by Ayurvedic physicians for a variety of conditions, including osteoarthritis, rheumatoid arthritis, diarrhea, dysentery, pulmonary disease, and ringworm.

Dried extracts of the resin of the Boswellia serrata tree contain anti-inflammatory triterpenoids called boswellic acids. All boswellic acids have a pentacyclic structure based on 12-ursen-24-oic acid with differing substituents.

According to scientific and clinical research, Boswellia:

Inhibits proinflammatory 5-lipoxygenase and blocks leukotriene synthesis*
Improves blood supply to the inflamed tissues and helps to repair damaged blood vessels*
Interferes with enzymes that contribute to inflammation and pain*
Helps to reduce joint aching and stiffness*
Blocks white cell activity in damaged tissue*
Improves symptoms of ulcerative colitis (inflammatory bowel disease), including abdominal pains, loose stools, and mucus and blood in the stools*
Reduces fluid retention associated with tumors*

*These statements have not been evaluated by the Food and Drug Administration.

Reference:

Cuaz-Perolin C. et al. Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. Arteriosclerosis, Thrombosis & Vascular Biology. 28(2):272-7, 2008
Madisch A. et al. Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial. International Journal of Colorectal Disease. 22(12):1445-51, 2007
Moussaieff A. et al. Mechoulam R. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Molecular Pharmacology. 72(6):1657-64, 2007
Gayathri B. et al. Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases. International Immunopharmacology. 7(4):473-82, 2007
Flavin DF. A lipoxygenase inhibitor in breast cancer brain metastases. Journal of Neuro-Oncology. 82(1):91-3, 2007
Banno N. et al. Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. Journal of Ethnopharmacology. 107(2):249-53, 2006
Borrelli F. et al. Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation. British Journal of Pharmacology. 148(4):553-60, 2006
Roy S. et al. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. Antioxidants & Redox Signaling. 8(3-4):653-60, 2006
Fan AY. Et al. Berman BM. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats. Journal of Ethnopharmacology. 101(1-3):104-9, 2005
Chevrier MR. et al. Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro. Clinical & Diagnostic Laboratory Immunology. 12(5):575-80, 2005
Kiela PR. Et al. Effects of Boswellia serrata in mouse models of chemically induced colitis. American Journal of Physiology – Gastrointestinal & Liver Physiology. 288(4):G798-808, 2005
Kimmatkar N. et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee-a randomized double blind placebo controlled trial. Phytomedicine. 10(1):3-7, 2003